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Intermittent Exercise, Fasting, and OB Gene Expression
December 12, 2007 09:07 AM
So many seem to doubt the benefits of exercise for weight reduction or, more importantly, body composition, the true measure of fitness. They focus on caloric balance and the apparently small effect of exercise on energy balance, but that is only part of the equation for body composition. Hormone drives, stress resistance, and insulin sensitivity are all driven by exercise. Provided one doesn't go too far into the unhealthful range for exercise, all these contributing factors to body composition are favorably altered by exercise. Moreover, caloric balance studies are all confounded by incorrect reporting of total intake and even errors in energy expenditures. These are so difficult to do in free-living humans, that little confidence ought to be placed in them, least of all a pessimistic conclusion as to the effects of exercise.
But, there is more. Exercise affects gene expression in a highly favorable way. Exercise induces transient changes in energy balance and this is a signal to gene expression. Intermittent exercise, in the Evolutionary Fitness style, does not go "over the curve" into the destructive range for exercise and induces a down regulation of the fat gene expression, the OB gene (short for obesity gene). Intermittent fasting also down regulates OB gene expression. Eating the EF Way reduces insulin and down regulates OB gene expression. Living a low stress lifeway by not over doing exercise or obsessing over food and practicing intermittent episodes of brief intense exercise mixed with languid rest and "just doing" simple things also turns sympathtic tone up and down intermittently and, in turn, closes down insulin and OB gene expression. Looks like the EF combination, which aims at all these events, is great for attaining and keeping your healthy body composition.
Have a look at this abstract...
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 225, 747–750 (1996)
ARTICLE NO. 1245
The Effect of Exercise on ob Gene Expression
Donghai Zheng, Margaret H. Wooter, Qian Zhou, and G. Lynis Dohm1
Department of Biochemistry, East Carolina University School of Medicine, Greenville, North Carolina 27858
Received July 18, 1996
Expression of the ob gene is subject to nutritional as well as hormonal regulation to control fat storage.
In the present study we investigated the effect of acute exercise and long-term exercise training on ob mRNA levels in rat adipose tissue. Northern blot analysis showed that a single bout of exercise significantly decreased ob mRNA levels approximately 30% immediately and 3 hr after exercise. After 4 weeks of exercise training the ob mRNA level was significantly decreased approximately 48% at 2 hr after the last training session compared to the control group. These data demonstrated that exercise has a transient effect on ob gene expression and suggest that regulation of ob gene expression may help control energy balance following exercise. q 1996 Academic Press, Inc.
Obesity is a major risk factor for several human diseases including non-insulin-dependent
diabetes disease, cardiovascular disease, and hypertension. The cloning of the obese (ob) gene has provided new insight into the molecular mechanisms underlying obesity by regulating energy intake, expenditure and storage (1). The ob gene appears to be expressed exclusively in adipose tissue and its encoded protein, named leptin, may act as a satiety factor and also affects overall energy expenditure (2,3). A single mutation of ob gene in mice causes marked hereditary obesity (1). In the adipose tissue of genetically obese db/db mice (4) and Zucker fatty rats (5), the ob gene expression was up-regulated. Expression of the ob gene is subject to nutritional and energy balance regulation as well as hormonal regulation. Fasting was reported to suppress ob gene expression and it was reversed by refeeding (6, 7). The ob gene expression is also up-regulated by insulin (7,8) and down-regulated by catecholamines and sympathetic activity (9,10).
Exercise exerts an immediate and substantial increase in energy expenditure and is an
important part of a successful long-term weight-control program (11). Therefore it was of
interest to investigate how expression of the ob gene might be acutely or chronically regulated by exercise and training. In the present study, we examined rat ob mRNA level in adipose tissue after acute exercise and 4 weeks of exercise training.
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Comments
Art, you write: "So many seem to doubt the benefits of exercise for weight reduction or, more importantly, body composition, the true measure of fitness."
Body composition is a static measure: height, weight, tape measurements, ratios etc. But I see fitness as something that is determined only dynamically, and even then in relation to the purposes to which the body is put: e.g., activity, health, well-being, longevity, willingness to be active, gracefulness etc. Body composition varies mainly with sex and age as well as the usual suspects: activity, disease and diet.
So I don't think we can look at a person and say whether they are fit or not. But I certainly agree with the rest of this post.
Regards
Posted by: Keith Thomas
at December 14, 2007 3:34 AM
People are brainwashed by the constant pounding of the "fitness industry" and so-called experts who are associated with it. However, the industry understands, quite well, that fitness can't be too "difficult" or they lose their clients. I have a friend who's a personal trainer and he would never consider training most of his clients in an EF sort of way. They simply wouldn't return, "it's too hard!"
So, you get the steady state treadmill work...
As Art has said many times, "this is easy..." And, it really is. Short, intense work, mixed randomly with active rest.
I love to mix the workouts. Art seems to favor weights. I like weights but also find ways to include intense body weight exercises, plyometrics, isometrics, and sprint work. I mix and match and never get bored.
I can't wait for the book....I'll pay whatever he asks! ;-)
Posted by: TonyB
at December 13, 2007 8:05 AM
I have a question that is somewhat related to this. Namely the net caloric effect of building a pound of new muscle. I have searched a decent bit online, and have found nothing from a credible source, and numbers that range from impossibly small to impossibly large (700 to 45,000). Both of the extremes were based on textbook value calculations, e.g. assuming it takes the same number of calories to build a pound of new muscle as the body would harvest by consuming it either as food or as a product of starvation. Which seems to me to be hopelessly simple. On the other extreme was an article that was calculating the energy requirement to create all of the chemical bonds in that quantity of muscle, which seems to me to be a hopelessly complex analysis, and one which I place little credence on.
Have you found a value for this in your reading that you feel is credible? Or a ballpark estimate? The reason I ask is that depending on the true value this would dramatically change the argument about the weight loss effects of steady state cardio versus some form of HIIT or weight training.
The arguments I have seen so far look at this system as if it is evaluation the simple equation of calories burnt during cardio versus the calories burnt from weight training and the resting calories burnt by carrying extra muscle. This seems to be assuming that the creation of muscle is 'free' in a caloric sense.
I have been thinking about what would be required to measure this value, and it seems like it would be very expensive and difficult, because one would have to measure both the calories actively burned by activity and the calories consumed over a period of time long enough for participants to gain measurable amounts of muscle. As well as accurately measuring body composition. So the number of participants as well as the time period required for a statistically significant result seems beyond the scope of most modern studies.
If you have any insight into this I would be fascinated to hear them.
By the way this is my first post, but I have been reading and enjoying your blog for quite a while now.
Yours,
Malcolm
Posted by: greateraias
at December 13, 2007 7:21 AM
I think the critical point here is what everyone conceives as exercise. Part of the reason that Gary Taubes is down on exercise is that what he is talking about is the steady (static) tied-to-a-treadmill exercise that many think must be done 5 days a week. This is exactly the opposite of the intermittent exercise that Art is advocating, both in number of days exercising and in style of exercise. However, Taubes conception of exercise is the majority's. If so many people think a marathoner looks fit, they are going to try to emulate, in their way, the marathoner's exercise regime. Having been fed this logic, it's hard to believe Art for many, so that no exercise seems almost as logical as exercise differently.
Posted by: Elam Bend
at December 12, 2007 10:51 AM
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