Arthur De Vany's Evolutionary Fitness
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Recent articles
The Male Biological Clock
Jun 28, 2011
Well, it is not quite a clock. It is the accumulations of mutations in sperm that makes the offspring of older males more apt to exhibit genetically-related diseases.
The Triage Theory of Aging or Stress
Jun 3, 2011
Bruce Ames is a highly respected researcher in aging. He has proposed a micronutrient theory of aging that has an evolutionary foundation. I post the abstract of his paper in this preview and then go into an extended discussion by of the theory and Dr. Heyhighen's excellent discussion of theories of aging. I strongly recommend that you visit his site at
ECCO
.
Inadequate dietary intakes of vitamins and minerals are widespread, most likely due to excessive consumption of energy-rich, micronutrient-poor, refined food. Inadequate intakes may result in chronic metabolic disruption, including mitochondrial decay. Deficiencies in many micronutrients cause DNA damage, such as chromosome breaks, in cultured human cells or in vivo. Some of these deficiencies also cause mitochondrial decay with oxidant leakage and cellular aging and are associated with late onset diseases such as cancer. I propose DNA damage and late onset disease are consequences of a triage allocation response to micronutrient scarcity. Episodic shortages of micronutrients were common during evolution. Natural selection favors short-term survival at the expense of long-term health. I hypothesize that short-term survival was achieved by allocating scarce micronutrients by triage, in part through an adjustment of the binding affinity of proteins for required micronutrients. If this hypothesis is correct, micronutrient deficiencies that trigger the triage response would accelerate cancer, aging, and neural decay but would leave critical metabolic functions, such as ATP production, intact. Evidence that micronutrient malnutrition increases late onset diseases, such as cancer, is discussed. A multivitamin-mineral supplement is one low-cost way to ensure intake of the Recommended Dietary Allowance of micronutrients throughout life.
Aging post from the Archives
May 17, 2011
This is a very brief post from August, 2005. We are putting the archives on line gradually.
I don't worry at all about my cholesterol
Apr 20, 2011
Its not high anyway, but there is scant science, correctly done, to make me worry. You worry if you want to.
Check Dr.
Ravnskov's
interview with Jimmy Moore and come away from it shocked.
The telomere/mitochondria axis of ageing
Apr 5, 2011
We are going to hear much more about the cross-talk between telomeres and mitochondria. The New Evolution Diet, as far as I know, is the only book to discuss the importance of mitochondria and telomeres.
Christopher Walken
Feb 24, 2011
Yesterday, someone said I look like a young Chrisopher Walken.
Cellular Entropy
Feb 15, 2011
Increasing disorder within the cell is an instance of disorder, or entropy. Disorder is often called chaos, sometimes loosely. The loss of internal order is a form of disinformation. There are many such sources of damage or accumulation of disfunctional tissues inside the cell that lead to a loss of internal order. We have seen how autophagy clears out damaged tissues inside cells. Now, it is found that the accumulation of unneeded proteins, the elements that are cleaned up through autophagy, result in cellular disorder and death.
Potential Paradigm Busters, Part 1: Viral Infection and Cardiovascular Disease
Nov 27, 2010
I am weary of hearing the same old, unsupported, dogmas about health. The same old villians keep turning up in reports, but the new ideas, often better supported and having real physiological mechanisms behind them, are neglected. It seems part of the reason is that these new ideas don't support interventions in how you live and what you eat or do. So, I plan to look at a few such instances, beginning with heart disease. The short answer is that heart disease is best explained by a viral infection.
Do you recall how the theory that a bacterial infection caused ulcers was rejected and then demonstrated by the doctor taking a dose of H. Pylori and developing an ulcer? He then cured the ulcer using a antibiotic that targeted H. Pylori. It was long thought that stress and stomach acid and all sorts of other things were involved. Of course, the acid and the inflammation in the stomach were attempts to kill the bacteria; they were not the "cause".
I think we are at about the same stage when it comes to atherosclerosis where wide spread inflammation of the blood vessels, adhesion of foam cells to the wall, and proliferation of cells and swelling of the vascular lining all seem to be the result of the immune system attacking a pathogen.
Life as a Chrony: how it is to chronically restrict calories
Oct 26, 2010
I got a big kick out of this
New York Magazine
article about a reporter who tried to live with chronic caloric restriction. Hard to do. And not as effective as EF.
Super Mike's Progress Report
Jun 30, 2010
Mike has been around my blog for quite some time, about 5 years. He made amazing progress and now sends me an annual progress report. At 57, he is setting new standards for what a male can look like.
more articles >>