Inflammation/Oxidation

Recent articles

ADHD and Diet Jan 11, 2012: Finally, a review of studies on this subject. Here is the LINK.

Loren Cordain on MS Dec 10, 2011: Following up on our earlier post on MS is this tour d'force on MS and diet by Loren Cordain. Just great science and a great scientist.

Notice the molecular mechanisms. The Paleo Diet is not just mimicking the Stone Age, it is based on genetics, epigentic influences, and molecular details.

Ketogenic Diet and Mitochondrial GSH Jul 28, 2011: Glutathione (GSH) is the primary guardian of the mitochondrial redox status (its state of reduction or oxidation). An important article in the Journal of Neurochemistry demonstrates that the ketogenic diet up-regulates GSH biosynthesis, enhances mitochondrial antioxidant status, and protects mtDNA from oxidant-induced
damage.

Glutathione, the master antioxidant and detoxifer Jul 3, 2011: I seldom refer to the HuffingtonPost, but this article is worthwhile as a popular explanation of the role of glutathione and its cooperation with alpha lipoic acid, vit C, E, B6, and related B vitamins, and sources of sulpher in your food.

Competition for Glutathione and Chronic Fatigue Syndrome Jun 24, 2011: The immune system and muscle tissue compete for glutathione (GSH); the immune system uses it to protect the lympocytes from the oxidation they use to destroy pathogens, and muscle uses it to protect the mitochondria and the cellular DNA from the reactive oxygen species that result from exercise. When you over exercise, you deplete the GSH that is available to the immune system. So, you may get sick. When you get an infection, you deplete the GSH available to your muscle and you get fatigued.

Glutathione, Aging and Cancer Jun 15, 2011: Here is a bit more on why I think supplementing with glutathione (GSH) is a good practice as we get older. The mechanisms through which GSH reduces aging and prevents cancer are described (to the extent they are known, there may be others such as preventing cell senescence of cells by reducing oxidation of telomeres so that the Hayflick limit is not hit).

Glutathione in HIV-Positive Patients Jun 15, 2011: HIV-positive patients acquire glutathione deficiency. Glutathione is called the master antioxidant because it is central to controlling ROS, free radicals that damage cells. In addition to HIV-positives, diabetics, and asthmatics also develop a pathogenic deficiency of glutathione. Drs. Demopoulus, Seligman, Ollerenshway and Richie recently presented the results of a clinical trial of a bioavailable glutathione, Ultrathione, in HIV-positive patients, whose acquired deficiency is well-established and used as a model of glutathione deficiency. Intracellular repletion of glutathione was demonstrated within 30 minutes of dosing. As many of you may know by now, I have taken Ultrathione for more than 25 years and believe it is an important factor in how I age.

Is Systemic Inflammation Dissolving the Body into a Sloshy Blob? Sep 20, 2010: Everybody who stays with WW and me for a few days at our home drops pounds and years from their appearance. Their faces notably regain their jaw line and their necks reappear if they come with more than a few pounds of extra weight. Their faces lose a lot of redness and wrinkles and the puffiness and swelling seem to melt off. They lose more volume to their faces and bodies than their loss of weight can explain.

Caloric Restriction or Low Insulin as anti-aging strategies Jun 22, 2010: Which is better? It turns on the production of ROS in the mitochondria. We enjoy the easier way of slowing aging when we do EF.

Hair and hormones Feb 15, 2010: I don’t agree with the usual diagnosis of male pattern baldness. It is reactive oxygen species (ROS) that causes hair loss, not having too much testosterone (T). The hair follicles are inflammed. You can even see it.